Seven new metabolites of drostanolone heptanoate by using Beauveria bassiana , and Macrophomina phaseolina cell suspension cultures RSC Advances RSC Publishing DOI:10 1039 C9RA05878H

The present study reports the biotransformation of an anabolic-androgenic steroid (AAS) drostanolone heptanoate (1) by using two microbial cultures, Beauveria bassiana, and Macrophomina phaseolina. Phaseolina it afforded two new 7–8, and two known 9–10 metabolites. The main sites of hydroxylation in the steroidal skeleton of 1 were at C-5, C-7, C-11, C-14, C-15, and C-20, hydrolysis of the ester moiety at C-17, and reduction of the carbonyl group at C-3. The structures of the transformed products were determined by using mass, NMR, and other spectroscopic techniques.

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• The main sites of hydroxylation in the steroidal skeleton of 1 were at C-5, C-7, C-11, C-14, C-15, and C-20, hydrolysis of the ester moiety at C-17, and reduction of the carbonyl group at C-3.

Our skilled professionals only use high quality chemical compounds and progressive technology while processing these products. In order to ensure quality, offered products are stringently checked on various parameters. As per the varied requirements of our esteemed clients, we provide Drostanolone Propionate in various packaging options and at affordable prices. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor.

Structure

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• For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver.
• In order to ensure quality, offered products are stringently checked on various parameters.
• If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given.

In continuation of our structural transformation studies on steroidal drugs,14–20 biotransformation of drostanolone heptanoate (1) was carried out. The purpose of this study was to synthesize structurally diverse analogues of drostanolone heptanoate (1) for their potential use in the biomedical research, by employing mild, and low-cost biotransformation procedures. Calculated molecular properties are available for small molecules and natural products (not peptides). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. Samex Overseas is a leading Manufacturer, Exporter and Supplier of best quality Drostanolone Propionate Active Pharma Ingredients (API).

Player banned for 4 years after positive test for bodybuilding drug Drostanolone

For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided. It was reported that Kumar tested positive for a banned substance called anabolic steroid drostanolone metabolite on the day of the race. If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. A sprinter who ran a 100m final all by himself after his seven rivals fled drug testers has failed a drug test. The 40 year-old rugby player tested positive for the presence of the prohibited substances Drostanolone and Trenbolone (metabolite 17-epitrenbolone).

• In continuation of our structural transformation studies on steroidal drugs,14–20 biotransformation of drostanolone heptanoate (1) was carried out.
• Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor.
• As per the varied requirements of our esteemed clients, we provide Drostanolone Propionate in various packaging options and at affordable prices.
• The structures of the transformed products were determined by using mass, NMR, and other spectroscopic techniques.
• All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand.
• You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.